MetaGene is a supplier of over 800,000 antibodies from USA, Canada, UK and Sweden manufacturers.
Some of our more popular antibodies (with links to the manufacturers) include:
SOX10 (Biocare Medical)
The SOX10 protein is widely expressed in normal human tissues including melanocytes and breast tissue. It is also an important marker in malignant tumors such as melanoma, breast carcinoma, gliomas and benign tumors such as schwannomas. SOX10 antibody has been shown to be expressed in 97-100% of desmoplastic and spindle cell melanomas and was also shown to be expressed in 100% of nevi. The majority of oligodendrogliomas but also a large percentage of astrocytomas and poorly differentiated glioblastomas have also been shown to express SOX10. PATENT PENDING.
p63 (Biocare Medical)
p53 homologue p63 encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives. p63 is detected in prostatic basal cells in normal prostate; however, it is negative in malignant tumors of the prostate gland. Thus p63 antibody may be a valuable tool in the differential diagnosis of benign and malignant tumors of prostate gland and can be used in a panel of antibodies such as HMW CK [34ßE12], PSA and PSAP. p63 may play a significant role in prostate development by maintaining a prostate stem cell population. Striated muscle staining may be observed with p63.
P40 (Biocare Medical)
The mouse monoclonal antibody p40 [BC28] recognizes an epitope unique to the p40 protein and may have applications in cases where p63 has traditionally been used. p63 [4A4] recognizes both the p63 and p40 proteins. As a result, p63 suffers from specificity limitations due to reactivity in a subset of lung adenocarcinomas (ADC). In contrast, p40 is selectively expressed in lung Squamous cell carcinoma (SqCC), offering an opportunity for improved specificity. p40 antibody (M) [BC28] recognizes an epitope unique to p40, which may result in diminished reactivity in lung ADC and increased specificity. Studies have supported routine use of p40 as an alternative for p63. In contrast to the rabbit polyclonal p40, p40 [BC28] does not stain macrophages.