FISH Imaging and Analysis

Metagene Pty Ltd, FISH Imaging Analysis


GenASIs FISH is a powerful tool for FISH technologists working in pathology and cytogenetic labs. With GenASIs FISH, labs can work faster and provided more accurate clinical results using innovative tools and an ideal workflow.

Faster Throughput

GenASIs FISH supports both manual and automated microscope capture, allowing labs to greatly increase efficiency.

Automated features include:

• Automated Z stacking, focus, enhancement and 3D data export
• Automatic XY coordinates
• Support for multiple filters and automated filter wheels

For tissue FISH, GenASIs FISH offers technologists “Tissue Match” – a tool that allows analysing the location of FISH scanning based on the cell morphology of the tissue stained with H&E or IHC and defined by the pathologist.

GenASIs FISH Software Modules

GenASIs FISHView is an image editing software that allows users to perform a myriad of enhancements, sharing and printing of the FISH imagery. With GenASIs FISHView, users can manually perform analysis on single FISH cells.

The GenASIs SpotScan application automatically analyses FISH cells. While FISHView performs analysis on one cell at a time, SpotScan analyses all cells in all fields of view. Within seconds, SpotScan is able to provide statistical analysis of all cells counted, showing the number of signals and other clinical data while classifying them into categories.

• Automatic segmentation based on morphological parameters and DAPI Intensity
• User defined cell clusters based on signal count or amplification ranges
• Detects and enumerates small and faint signals

Metagene Pty Ltd, FISH Imaging Analysis


GenASIs FISH performs many types of tests and applications.

• HER2
• UroVysion
• Fluorescent karyotyping

And many more.

GenASIs FISH is an open platform and new probe assays can easily be added at any time.

FDA cleared for the following GenASIs applications: ALK, BandView, FISHView, UroVysion, CEP XY & HER2/neu FISH and IHC family for: HER2,ER,PR and ki67.

Tissue Matching

Tissue Match is a tool for locating and marking a specific region of interest on FISH slides prior to scanning at high resolution. With Tissue Match, pathologists can scan a brightfield H&E slide to review and mark the exact region of interest for FISH scanning; which is automatically superimposed on the FISH slide. This guarantees that the clinically relevant area is analyzed correctly by the FISH technician.

Tissue Match begins with a tiled image of an H&E slide followed by a tiled image of FISH slide with a sequential tissue sample. Tissue Match aligns the tissue image on the two slides, and while marking regions of interest on the H&E slide, the system automatically marks the same area on the FISH slide. With clearly defined regions of interest, the FISH slide is then scanned at high resolution at the specific region chosen by the pathologist.

Metagene Pty Ltd, FISH Imaging Analysis

Metagene Pty Ltd, FISH Imaging Analysis


• Reduce FISH search and scan time
• Error free analysis
• Enhance clinical relevance and reliability
• Faster diagnostic workflow

FDA cleared for the following GenASIs applications: ALK, BandView, FISHView, UroVysion, CEP XY & HER2/neu FISH and IHC family for: HER2,ER,PR and ki67.

Robotic High-Throughput Tray Loader

Vastly increase throughput in your lab by integrating our robotic high throughput  tray loader. Equipped to handle 81+ slides, the robotic tray loader keeps the lab operating overnight, providing scanned images ready for analysis first thing in the morning.

A benefit of the full tray loader is the ability to continuously add new trays while in operation. A lab can have the robot running 24 hours a day by periodically inserting new trays into the loader for effectively infinite capacity.

Metagene Pty Ltd, FISH Imaging Analysis

Robotic Tray Loader Characteristics 

• Unattended continuous slides scan: non-stop tray replacement for continuous, infinite capacity
• Robotic precision
• Barcode reading for automatic case and sample identification
• Optional oil dispenser for unattended high magnification capture using oil objectives
• 9-slide trays to handle three cases of triple slide probes
• Desktop design with front loading transparent cover to view trays status

GenASIs Applications are FDA cleared for the following GenASIs applications: BandView, FISHView, CEP XY, UroVysion, ALK & HER2/neu FISH and IHC Family for: HER2, ER, PR and Ki67. All other products are for research purposes only, not intended for diagnostic or therapeutic use.

To find out more about Applied Spectral Imaging products click here.

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